| 1,755 | 9 | 14 |
| 下载次数 | 被引频次 | 阅读次数 |
益生菌在动物健康、疾病预防和修复中具有重要作用。益生菌在肠道定植是其长期、稳定地发挥益生作用的重要前提。然而，相较于益生菌的功能与应用，其在肠道的定植机制受到的关注明显不足。此外，不同种类益生菌在不同动物肠道中的定植具有差异性，且定植过程涉及多种因子。因此，益生菌在肠道的定植机制较为复杂。本文综述了益生菌来源的效应分子及其作用、肠道来源定植因子及其作用、肠道微生物对益生菌定植的影响及机制，以期为益生菌的高效利用及改善动物肠道健康提供科学依据。
Abstract：Probiotics play an important role in animal health, disease prevention and recovery. Intestinal colonization of probiotics is an important prerequisite for their long-term and stable probiotic role. However, compared with the function and application of probiotics, the colonization mechanism of probiotics in gut has received significantly less attention. In addition,the colonization of different kinds of probiotics in the intestines of different animals is different, and the colonization process involves multiple factors. Therefore, the colonization mechanism of probiotics in gut is more complex. This paper reviewed the effector molecules from probiotics and their effects, intestinal colonization factors and their effects, and the effects and mechanisms of intestinal microorganisms on the colonization of probiotics, which provides scientific basis for the efficient use of probiotics and the improvement of animal intestinal health.
[1] Fassarella M, Blaak E E, Penders J, et al. Gut microbiome stability and resilience:elucidating the response to perturbations in order to modulate gut health[J]. Gut, 2021, 70(3):595-605.
[2] Das Neves J, Sverdlov Arzi R, Sosnik A. Molecular and cellular cues governing nanomaterial–mucosae interactions:from nanomedicine to nanotoxicology[J]. Che Soc Rev, 2020,49(14):5058-5100.
[3] Abd El-Hack M E, El-Saadony M T, Shafi M E, et al. Probiotics in poultry feed:a comprehensive review[J]. J Anim Physiol Anim Nutr(Berl), 2020, 104(6):1835-1850.
[4] VilàB, Esteve-Garcia E, Brufau J. Probiotic micro-organisms:100 years of innovation and efficacy; modes of action[J]. World Poult Sci J, 2010, 66(3):369-380.
[5] Heilbronner S, Krismer B, Br?tz-Oesterhelt H, et al. The microbiome-shaping roles of bacteriocins[J]. Nat Rev Microbiol,2021, 19(11):726-739.
[6] de Vos W M, Tilg H, van Hul M, et al. Gut microbiome and health:mechanistic insights[J]. Gut, 2022, 71(5):1020-1032.
[7] ChoongGu L, Hyun C K, GiCheon K, et al. Exploring probiotic effector molecules and their mode of action in gut-immune interactions[J]. FEMS Microbiol Rev, 2023, 47(4), fuad046.
[8] Lock J Y, Carlson T L, Carrier R L. Mucus models to evaluate the diffusion of drugs and particles[J]. Adv Drug Deliv Rev,2018, 124:34-49.
[9] Nishiyama K, Sugiyama M, Mukai T. Adhesion properties of lactic acid bacteria on intestinal mucin[J]. Microorganisms,2016, 4(3):34.
[10] Wang C-M, Fernez M T, Woolston B M, et al. Native gastrointestinal mucus:critical features and techniques for studying interactions with drugs, drug carriers, and bacteria[J]. Adv Drug Deliv Rev, 2023, 200:114966.
[11] Arike L, Holmén-Larsson J, Hansson G C. Intestinal Muc2mucin O-glycosylation is affected by microbiota and regulated by differential expression of glycosyltranferases[J]. Glycobiology, 2017, 27(4):318-28.
[12] Samad T, Witten J, Grodzinsky A J, et al. Spatial configuration of charge and hydrophobicity tune particle transport through mucus[J]. Biophys J, 2022, 121(2):277-287.
[13] Marczynski M, Kimna C, Lieleg O. Purified mucins in drug delivery research[J]. Adv Drug Deliv Rev, 2021, 178:113845.
[14] Ehrencrona E, Van Der Post S, Gallego P, et al. The IgGFcbinding protein FCGBP is secreted with all GDPH sequences cleaved but maintained by interfragment disulfide bonds[J].Biol Chem, 2021, 297(1):100871.
[15] Barmpatsalou V, Dubbelboer I R, Rodler A, et al. Physiological properties, composition and structural profiling of porcine gastrointestinal mucus[J]. Eur J Pharm Biopharm, 2021, 169:156-167.
[16] Desai M S, Seekatz A M, Koropatkin N M, et al. A dietary fiber-deprived gut microbiota degrades the colonic mucus barrier and enhances pathogen susceptibility[J]. Cell, 2016, 167(5):1339-1353.e21.
[17] Korpela K, Helve O, Kolho K L, et al. Maternal fecal microbiota transplantation in cesarean-born infants rapidly restores normal gut microbial development:a proof-of-concept study[J].Cell, 2020, 183(2):324-334.e5.
[18] Alessandri G, van Sinderen D, Ventura M. The genus Bifidobacterium:from genomics to functionality of an important component of the mammalian gut microbiota[J]. Comput Struct Biotechnol J, 2021, 19:1472-1487.
[19] Kwoji I D, Aiyegoro O A, Okpeku M, et al. Multi-strain probiotics:synergy among isolates enhances biological activities[J].Biology, 2021, 10(4):322.
[20] Thorakkattu P, Khanashyam A C, Shah K, et al. Postbiotics:current trends in food and pharmaceutical industry[J]. Foods,2022, 11(19):3094.
[21] Xinzhou W, Peng Z, Xin Z. Probiotics regulate gut microbiota:an effective method to improve immunity[J]. Molecules, 2021,26(19):6076.
[22] Bui T P N, Manner?s-Holm L, Puschmann R, et al. Conversion of dietary inositol into propionate and acetate by commensal Anaerostipes associates with host health[J]. Nat Commun,2021, 12(1):4798.
[23] Nishiyama K, Yokoi T, Sugiyama M, et al. Roles of the cell surface architecture of bacteroides and bifidobacterium in the gut colonization[J]. Front Microbiol, 2021, 12:754819.
[24] Nishiyama K, Takaki T, Sugiyama M, et al. Extracellular vesicles produced by bifidobacterium longum export mucinbinding proteins[J]. Appl Environ Microbiol, 2020, 86(19):e01464-20.
[25] Sasaki N, Miyamoto K, Maslowski K M, et al. Development of a scalable coculture system for gut anaerobes and human colon epithelium[J]. Gastroenterology, 2020, 159(1):388-390.e5.
[26] Hao H, Zhang X, Tong L, et al. Effect of extracellular vesicles derived from lactobacillus plantarum q7 on gut microbiota and ulcerative colitis in mice[J]. Front Immunol, 2021, 12:777147.
[27] Morishita M, Sagayama R, Yamawaki Y, et al. Activation of host immune cells by probiotic-derived extracellular vesicles via tlr2-mediated signaling pathways[J]. Biol Pharm Bull, 2022,45(3):354-359.
[28] Rohith H S, Halami P M. In vitro validation studies for adhesion factor and adhesion efficiency of probiotic Bacillus licheniformis MCC 2514 and Bifidobacterium breve NCIM 5671on HT-29 cell lines[J]. Arch Microbiol, 2021, 203(6):2989-2998.
[29] Korcz E, Varga L. Exopolysaccharides from lactic acid bacteria:Techno-functional application in the food industry[J]. Trends Food Sci Technol, 2021, 110:375-384.
[30] Feng X, Zhang H, Lai P F H, et al. Structure characterization of a pyruvated exopolysaccharide from Lactobacillus plantarum AR307[J]. Int J Biol Macromol, 2021, 178:113-120.
[31] Ren Q, Tang Y, Zhang L, et al. Exopolysaccharide produced by lactobacillus casei promotes the differentiation of CD4+T cells into Th17 cells in BALB/c mouse peyer’s patches in vivo and in vitro[J]. J Agric Food Chem, 2020, 68(9):2664-2672.
[32] Feng X W, Zhang H, Lai P F H, et al. Structure characterization of a pyruvated exopolysaccharide from Lactobacillus plantarum AR307[J]. Int J Biol Macromol, 2021, 178:113-120.
[33] Xiaoqing X, Yu Q, Qing P, et al. Antioxidant and immunomodulatory properties of partially purified exopolysaccharide from lactobacillus casei isolated from chinese northeast sauerkraut[J]. Immunol Invest, 2021, 51(4)748-765.
[34] Lanxin Y, Bingxin C, Shiyan C, et al. Exopolysaccharides from bifidobacterium animalis ameliorate escherichia coli-induced IPEC-J2 cell damage via inhibiting apoptosis and restoring autophagy[J]. Microorganisms, 2021, 9(11)2363.
[35] Han S, Lu Y, Xie J, et al. Probiotic gastrointestinal transit and colonization after oral administration:a long journey[J]. Front Cell Infect Microbiol, 2021, 11:609722.
[36] Fang J. Slimy partners:the mucus barrier and gut microbiome in ulcerative colitis[J]. Exp Mol Med, 2021, 53:1-6.
[37] Muscariello L, de Siena B, Marasco R. Lactobacillus cell surface proteins involved in interaction with mucus and extracellular matrix components[J]. Curr Microbiol, 2020, 77(12):3831-3841.
[38] Colautti A, Arnoldi M, Comi G, et al. Antibiotic resistance and virulence factors in lactobacilli:something to carefully consider[J]. Food Microbiol, 2022, 103:103934.
[39] Rossi F, Amadoro C, Pallotta M L, et al. Variability of genetic characters associated with probiotic functions in lacticaseibacillus species[J]. Microorganisms, 2022, 10(5):1023.
[40] Nataraj B H. Extractable surface proteins of indigenous probiotic strains confer anti-adhesion knack and protect against methicillin-resistant Staphylococcus aureus induced epithelial hyperpermeability in HT-29 cell line[J]. Microb Pathog, 2021,158:104974.
[41] Chen P C, Hsieh M H, Kuo W S, et al. Moonlighting glyceraldehyde-3-phosphate dehydrogenase(GAPDH)protein of Lactobacillus gasseri attenuates allergic asthma via immunometabolic change in macrophages[J]. J Biomed Sci, 2022,29(1):75.
[42] Deng Z, Dai T, Zhang W, et al. Glyceraldehyde-3-phosphate dehydrogenase increases the adhesion of lactobacillus reuteri to host mucin to enhance probiotic effects[J]. Int J Mol Sci, 2020,21(24):9756.
[43] Harvey K L, Jarocki V M, Charles I G, et al. The diverse functional roles of elongation factor Tu(EF-Tu)in microbial pathogenesis[J]. Front Microbiol, 2019, 10:2351.
[44] Nishiyama K, Sugiyama M, Mukai T. Adhesion properties of lactic acid bacteria on intestinal mucin[J]. Microorganisms,2016, 4(3):34.
[45] Ronkainen A, Khan I, Krzy?ewska-Dudek E, et al. In vitro adhesion, pilus expression, and in vivo amelioration of antibiotic-induced microbiota disturbance by Bifidobacterium spp. strains from fecal donors[J]. Gut Microbes, 2023, 15(1):2229944.
[46] Raheem A, Liang L, Zhang G, et al. Modulatory effects of probiotics during pathogenic infections with emphasis on immune regulation[J]. Front Immunol, 2021, 12:616713.
[47] Yadav M, Chauhan N S. Overview of the rules of the microbial engagement in the gut microbiome:a step towards microbiome therapeutics[J]. J Appl Microbiol, 2021, 130(5):1425-1441.
[48] Cortes-Perez N G, de Moreno de LeBlanc A, Gomez-Gutierrez J G, et al. Probiotics and trained immunity[J]. Biomolecules,2021, 11(10):1402.
[49] Witten J, Samad T, Ribbeck K. Selective permeability of mucus barriers[J]. Curr Opin Biotechnol, 2018, 52:124-133.
[50] Kankainen M, Paulin L, Tynkkynen S, et al. Comparative genomic analysis of Lactobacillus rhamnosus GG reveals pili containing a human-mucus binding protein[J]. Proc Natl Acad Sci U S A, 2009, 106(40):17193-17198.
[51] Tian P, Zou R, Wang L, et al. Multi-Probiotics ameliorate Major depressive disorder and accompanying gastrointestinal syndromes via serotonergic system regulation[J]. J Adv Res,2023, 45:117-125.
[52] Naghmouchi K, Drider D, Fliss I. Purification of pediocin PA-1by immunoaffinity chromatography[J]. J AOAC Int, 2008,91(4):828-832.
[53] Donaldson G P, Ladinsky M S, Yu K B, et al. Gut microbiota utilize immunoglobulin A for mucosal colonization[J]. Science,2018, 360(6390):795-800.
[54] Eshrati M, Amadei F, Van De Wiele T, et al. Biopolymer-based minimal formulations boost viability and metabolic functionality of probiotics lactobacillus rhamnosus GG through gastrointestinal passage[J]. Langmuir, 2018, 34(37):11167-11175.
[55] Yao M, Li B, Ye H, et al. Enhanced viability of probiotics(Pediococcus pentosaceus Li05)by encapsulation in microgels doped with inorganic nanoparticles[J]. Food Hydrocolloids,2018, 83:246-252.
[56] Alehosseini A, Gomez Del Pulgar E M, Fabra M J, et al. Agarose-based freeze-dried capsules prepared by the oil-induced biphasic hydrogel particle formation approach for the protection of sensitive probiotic bacteria[J]. Food Hydrocolloids, 2019,87:487-496.
[57] Shepherd E S, DeLoache W C, Pruss K M, et al. An exclusive metabolic niche enables strain engraftment in the gut microbiota[J]. Nature, 2018, 557(7705):434-438.
[58] Wu X W, Su J X, Wei J Z, et al. Recent advances in threedimensional stem cell culture systems and applications[J].Stem Cells Int, 2021, 2021(1):9477332.
[59] Miyoshi H, Stappenbeck T S. In vitro expansion and genetic modification of gastrointestinal stem cells in spheroid culture[J]. Nat Protoc, 2013, 8(12):2471-2482.
[60] Zhao D, Farnell M B, Kogut M H, et al. From crypts to enteroids:establishment and characterization of avian intestinal organoids[J]. Poult Sci, 2022, 101(3):101642.
[61] Wang Y, Hou Q, Wu Y, et al. Methionine deficiency and its hydroxy analogue influence chicken intestinal 3-dimensional organoid development[J]. Anim Nutr, 2022, 8:38-51.
[62] Pompili S, Latella G, Gaudio E, et al. The charming world of the extracellular matrix:a dynamic and protective network of the intestinal wall[J]. Front Med(Lausanne), 2021, 8:610189.
[63] Li Y, Niu H M, Guo Y X, et al. Crypt-like patterned electrospun nanofibrous membrane and probiotics promote intestinal epithelium models close to tissues[J]. Appl Microbiol Biotechnol, 2023, 107(13):4395-4408.
[64] Hu M, Li Y, Huang J, et al. Electrospun scaffold for biomimic culture of Caco-2 cell monolayer as an in vitro intestinal model[J]. ACS Appl Bio Mater, 2021, 4(2):1340-1349.
[65] Lee S M, Donaldson G P, Mikulski Z, et al. Bacterial colonization factors control specificity and stability of the gut microbiota[J]. Nature, 2013, 501(7467):426-429.
基本信息:
DOI：10.19556/j.0258-7033.20240130-01
中图分类号:S852.6
引用信息:
[1]杨靖,管军军,崔耀明,等.益生菌在肠道的定植机制研究进展[J].中国畜牧杂志,2025,61(02):82-88+98.DOI:10.19556/j.0258-7033.20240130-01.
基金信息:
河南工业大学自然科学基金创新项目（2022ZKCJ17）
2024-12-27
2024-12-27
2024-12-27