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2024 12 v.60 12-17
哺乳动物精子冷冻氧化损伤以及抗氧化剂的应用研究进展
基金项目(Foundation): 云南省2023年度“彩云博士后计划”创新项目(530000241100002811678); 国家绒毛用羊产业技术体系(CARS-39)
邮箱(Email): waltq20020109@163.com;
DOI: 10.19556/j.0258-7033.20240630-06
中文作者单位:

云南省畜牧兽医科学院;云南农业大学动物医学院;

摘要(Abstract):

精液冷冻保存是长期保护雄性生育力、转基因系、濒危物种种质资源的一个重要手段。冷冻保存的精液能跨越时空限制,有助于人工授精和体外受精等生殖技术快速发展。然而,冷冻-解冻过程会使精子遭受物理性、化学性以及氧化性损伤,导致冻融精子质量显著下降,影响其受精能力。其中,氧化性损伤主要表现为冷冻胁迫条件下精子的抗氧化防御系统被过量的活性氧(ROS)所淹没而形成的氧悖论状态,它被认为是冻融精子存活率及其受精能力下降的一个重要因素。目前,学者们正在尝试应用抗氧化剂来对抗过量ROS,从而平衡冷冻精子的抗氧化防御系统。本文主要综述了冷冻精子的氧化应激损伤、抗氧化剂的种类及其在精子冷冻保存中的应用现状,为深入研究抗氧化剂对冷冻精子的保护效应及其机制,以及进一步优化精液冷冻保存技术体系提供理论参考。

关键词(KeyWords): 精液;冷冻保存;活性氧;氧化应激;抗氧化剂
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基本信息:

DOI:10.19556/j.0258-7033.20240630-06

中图分类号:S813.3

引用信息:

[1]李春艳,杨琪格,贾宝瑜等.哺乳动物精子冷冻氧化损伤以及抗氧化剂的应用研究进展[J].中国畜牧杂志,2024,60(12):12-17.DOI:10.19556/j.0258-7033.20240630-06.

基金信息:

云南省2023年度“彩云博士后计划”创新项目(530000241100002811678); 国家绒毛用羊产业技术体系(CARS-39)

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